3D Culture Series - Part 1

Over the years, cell-based assays have been used by scientists for evaluating factors affecting disease and designing therapies to treat disease states. More recently, we have learned that the artificial cell environment provided by traditional plastic tissue culture impacts the cells’ biological program, and as a result, the information generated by these studies does not readily translate to living organisms. To address this deficiency, 3D culture models have been constructed that mimic the cells’ natural environment, promoting cellular differentiation as seen within living organisms. In these models, cells assemble into organotypic structures exhibiting both structural and functional features of their emanating tissues. While these models provide great advantages regarding efficacy, the presence of cell scaffolding proteins has complicated the adaptation of traditional techniques for analyzing cell culture.

This series will cover many aspects of 3D Culture including:

1. Background of 3D Culture
2. Assessing 3D Culture Cell Proliferation
3. Optimization of 3D Culture Cell Proliferation
4. Determining a Dose Response in 3D Culture

Additional information on 3D Products can be found at www.trevigen.com.