Cultrex® Human Basement Membrane Extract

Trevigen releases human placenta derived basement membrane extract providing a pathogen and xenographic free microenvironment for human cell research. Basement Membrane Extract (BME) can be used for promotion and maintenance of a specific phenotype in a variety of cell cultures including stem cells, primary epithelial cells, primary endothelial cells and smooth muscle cells.

A basement membrane extract derived from mouse EHS sarcoma is the historical standard with which research has been done on a variety of normal and cancer cells derived from both animal and human sources. While these models do demonstrate a physiological response, there are subtle differences in the composition of the extracellular matrix as a result of tissue source and species-specificity, as it is known that there are alterations in the tumor microenvironment, and mouse-specific proteins may impact the normal human cellular response.

As an option to avoid these issues, Trevigen has developed a BME derived from normal human placenta, avoiding the presence of both tumor-derived and mouse-specific proteins in the human cell microenvironment. The human BME has been functionally tested for compatibility with human cells. The human BME has also been tested for sterility, and further PCR tested to insure the absence of eight human pathogenic viruses including Hepatitis A, B and C, HIV 1 and 2, Hantaan, Seoul and Sin Nombre.

Trevigen, Inc. is a rapidly growing biotechnology company focused on the development of products and technology for cancer research, emphasizing apoptosis, DNA damage and repair, and cancer cell function and behavior. Trevigen has been a long-standing provider of quality reagents and kits for researchers investigating programmed cell death and DNA damage and repair. A logical extension of the focus on cancer research has been the recent development of assays for cancer cell function and behavior including angiogenesis, cell invasion and tumor formation. Currently, the product portfolio contains over 500 products categorized into four processes – Apoptosis, DNA Damage and Repair, Cancer Cell Behavior, and Oxidative Stress.

Trevigen, Inc. provides a complete line of specialized proteins for cell research, cancer cell assays and recently Mesenchymal stem cell differentiation products. Visit www.trevigen.com or contact us at 1-800-873-8443 or info@trevigen.com for more information.